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KMID : 0382619850050010309
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Hanyang Journal of Medicine
1985 Volume.5 No. 1 p.309 ~ p.316
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The Effect of Hyaluronidase, Dimethylsulfoxide and Actovegin on Experimental Skin Flap Survival
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Abstract
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Delay procedure has been used in reconstructive surgery for the prevention of flap necrosis and the augmentation of flap survival. Concerning the delay mechanism, numerous experiments have suggested various hypotheses. Recently, Finseth pro-posed a new vasodilatation hypotheses, based on the prolonged vascular smooth muscle relaxation in thepprecapillary arterioled to which several factors contribute such as sympathectomy, tissue ischemia and inflammatory reaction. Since then many authors attempted to improve flap survival with pharmacological treatment.
The study was conducted to reveal the effect of hyaluronidase, Actovegin and dimethyl sulfoxide on the survival of the random pattern flap in experimental rats.
The results were summarized as follows.
1. The mean length of the flap survival was 4.4Cm for the control and 6.7Cm for the flap treated with Dimethylsufoxide.
2. There was no significant difference between the DMSO-treated, Hyaluronidase treated and. Actovegin treated animals.
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